Impact of mediterranean diet promotion on environmental sustainability: a longitudinal analysis.

OBJECTIVE: This article aims to estimate the differences in environmental impact (greenhouse gas [GHG] emissions, land use, energy used, acidification and potential eutrophication) after one year of promoting a Mediterranean diet (MD). METHODS: Baseline and 1-year follow-up data from 5800 participants in the PREDIMED-Plus study were used. Each participant's food intake was estimated using validated semi-quantitative food frequency questionnaires, and the adherence to MD using the Dietary Score. The influence of diet on environmental impact was assessed through the EAT-Lancet Commission tables. The influence of diet on environmental impact was assessed through the EAT-Lancet Commission tables. The association between MD adherence and its environmental impact was calculated using adjusted multivariate linear regression models. RESULTS: After one year of intervention, the kcal/day consumed was significantly reduced (-125,1 kcal/day), adherence to a MD pattern was improved (+0,9) and the environmental impact due to the diet was significantly reduced (GHG: -361 g/CO2-eq; Acidification:-11,5 g SO2-eq; Eutrophication:-4,7 g PO4-eq; Energy use:-842,7 kJ; and Land use:-2,2 m2). Higher adherence to MD (high vs. low) was significantly associated with lower environmental impact both at baseline and one year follow-up. Meat products had the greatest environmental impact in all the factors analysed, both at baseline and at one-year follow-up, in spite of the reduction observed in their consumption. CONCLUSIONS: A program promoting a MD, after one year of intervention, significantly reduced the environmental impact in all the factors analysed. Meat products had the greatest environmental impact in all the dimensions analysed.

Eficacia del trasplante de células madre mesenquimales de lipoaspirado en el tratamiento de lesiones crónicas del manguito rotador. Modelo experimental en ratas / Efficacy of transplantation of lipoaspired mesenchymal stem cells in the treatment of chronic rotator cuff tears. Experimental model in rats

Antecedentes y objetivo: Las roturas del manguito rotador afectan aproximadamente al 30% de la población mayor de 60 años. El tratamiento quirúrgico por vía artroscópica de estas lesiones es el tratamiento de elección, sin embargo, a pesar de las mejoras técnicas de reparación el índice de rerroturas oscila entre el 11 y el 94%. Por ello, los investigadores buscan mejorar el proceso de curación biológica mediante el uso de diferentes alternativas como las células madre mesenquimales (MSC). Nuestro objetivo es evaluar la eficacia de un medicamento de terapia celular elaborado a partir de células madre alogénicas derivadas del tejido adiposo en un modelo de lesión crónica del manguito rotador en ratas. Material y método: Se creó la lesión del supraespinoso en 48 ratas para su posterior sutura a las 4 semanas. A 24 animales se les añadió las MSC en suspensión tras la sutura, y a 24 animales HypoThermosol-FRS® (HTS) como grupo control. En ambos grupos se analizó la histología (escala Åström y Rausing) y la carga máxima, desplazamiento y constante elástica del tendón supraespinoso a los 4 meses de la reparación. Resultados: No se encontraron diferencias estadísticamente significativas en la puntuación histológica comparando los tendones tratados con MSC con respecto a los tendones tratados con HTS (p=0,811) ni tampoco en los resultados de carga máxima (p=0,770), desplazamiento (p=0,852) ni constante elástica (p=0,669) del tendón en ambos grupos. Conclusiones: La adición en suspensión de células derivadas de tejido adiposo a la reparación de una lesión crónica de manguito no mejora las características histológicas ni biomecánicas del tendón suturado.(AU)

Background and aim: Rotator cuff tears emerge in approximately 30% of the population over 60 years of age. Arthroscopic surgical treatment of these lesions is the treatment of choice, however, despite the improved repair techniques, the rate of re-tears ranges between 11 and 94%. Therefore, researchers seek to improve the biological healing process through the use of different alternatives such as mesenchymal stem cells (MSCs). Our objective is to evaluate the efficacy of a Cellular Therapy Drug made from allogeneic stem cells derived from adipose tissue in a rat model of chronic rotator cuff injury. Material and methods: The supraspinatus lesion was created in 48 rats for subsequent suturing at 4 weeks. MSCs in suspension were added to 24 animals after suturing, and HypoThermosol-FRS® (HTS) to 24 animals as a control group. Histology (Åström and Rausing scale) and the maximum load, displacement and elastic constant of the supraspinatus tendon were analyzed in both groups 4 months after the repair. Results: No statistically significant differences were found in the histological score comparing the tendons treated with MSCs with respect to the tendons treated with HTS (P=.811) nor in the results of maximum load (P=.770), displacement (P=.852) or elastic constant (P=.669) of the tendon in both groups. Conclusions: The addition of adipose-derived cells in suspension to the repair of a chronic cuff injury does not improve the histology or biomechanics of the sutured tendon.(AU)

[Translated article] Efficacy of transplantation of lipoaspired mesenchymal stem cells in the treatment of chronic rotator cuff tears. Experimental model in rats / Eficacia del trasplante de células madre mesenquimales de lipoaspirado en el tratamiento de lesiones crónicas del manguito rotador. Modelo experimental en ratas

Antecedentes y objetivo: Las roturas del manguito rotador afectan aproximadamente al 30% de la población mayor de 60 años. El tratamiento quirúrgico por vía artroscópica de estas lesiones es el tratamiento de elección, sin embargo, a pesar de las mejoras técnicas de reparación el índice de rerroturas oscila entre el 11 y el 94%. Por ello, los investigadores buscan mejorar el proceso de curación biológica mediante el uso de diferentes alternativas como las células madre mesenquimales (MSC). Nuestro objetivo es evaluar la eficacia de un medicamento de terapia celular elaborado a partir de células madre alogénicas derivadas del tejido adiposo en un modelo de lesión crónica del manguito rotador en ratas. Material y método: Se creó la lesión del supraespinoso en 48 ratas para su posterior sutura a las 4 semanas. A 24 animales se les añadió las MSC en suspensión tras la sutura, y a 24 animales HypoThermosol-FRS® (HTS) como grupo control. En ambos grupos se analizó la histología (escala Åström y Rausing) y la carga máxima, desplazamiento y constante elástica del tendón supraespinoso a los 4 meses de la reparación. Resultados: No se encontraron diferencias estadísticamente significativas en la puntuación histológica comparando los tendones tratados con MSC con respecto a los tendones tratados con HTS (p=0,811) ni tampoco en los resultados de carga máxima (p=0,770), desplazamiento (p=0,852) ni constante elástica (p=0,669) del tendón en ambos grupos. Conclusiones: La adición en suspensión de células derivadas de tejido adiposo a la reparación de una lesión crónica de manguito no mejora las características histológicas ni biomecánicas del tendón suturado.(AU)

Background and aim: Rotator cuff tears emerge in approximately 30% of the population over 60 years of age. Arthroscopic surgical treatment of these lesions is the treatment of choice, however, despite the improved repair techniques, the rate of re-tears ranges between 11 and 94%. Therefore, researchers seek to improve the biological healing process through the use of different alternatives such as mesenchymal stem cells (MSCs). Our objective is to evaluate the efficacy of a Cellular Therapy Drug made from allogeneic stem cells derived from adipose tissue in a rat model of chronic rotator cuff injury. Material and methods: The supraspinatus lesion was created in 48 rats for subsequent suturing at 4 weeks. MSCs in suspension were added to 24 animals after suturing, and HypoThermosol-FRS® (HTS) to 24 animals as a control group. Histology (Åström and Rausing scale) and the maximum load, displacement and elastic constant of the supraspinatus tendon were analyzed in both groups 4 months after the repair. Results: No statistically significant differences were found in the histological score comparing the tendons treated with MSCs with respect to the tendons treated with HTS (P=.811) nor in the results of maximum load (P=.770), displacement (P=.852) or elastic constant (P=.669) of the tendon in both groups. Conclusions: The addition of adipose-derived cells in suspension to the repair of a chronic cuff injury does not improve the histology or biomechanics of the sutured tendon.(AU)

[Translated article] Efficacy of transplantation of lipoaspired mesenchymal stem cells in the treatment of chronic rotator cuff tears. Experimental model in rats.

BACKGROUND AND AIM: Rotator cuff tears emerge in approximately 30% of the population over 60 years of age. Arthroscopic surgical treatment of these lesions is the treatment of choice, however, despite the improved repair techniques, the rate of re-tears ranges between 11 and 94%. Therefore, researchers seek to improve the biological healing process through the use of different alternatives such as mesenchymal stem cells (MSCs). Our objective is to evaluate the efficacy of a cellular therapy drug made from allogeneic stem cells derived from adipose tissue in a rat model of chronic rotator cuff injury. MATERIAL AND METHODS: The supraspinatus lesion was created in 48 rats for subsequent suturing at 4 weeks. MSCs in suspension were added to 24 animals after suturing, and HypoThermosol-FRS® (HTS) to 24 animals as a control group. Histology (Åström and Rausing scale) and the maximum load, displacement and elastic constant of the supraspinatus tendon were analysed in both groups 4 months after the repair. RESULTS: No statistically significant differences were found in the histological score comparing the tendons treated with MSCs with respect to the tendons treated with HTS (P=0.811) nor in the results of maximum load (P=0.770), displacement (P=0.852) or elastic constant (P=0.669) of the tendon in both groups. CONCLUSIONS: The addition of adipose-derived cells in suspension to the repair of a chronic cuff injury does not improve the histology or biomechanics of the sutured tendon.

Efficacy of transplantation of lipoaspired mesenchymal stem cells in the treatment of chronic rotator cuff tears. Experimental model in rats. / Eficacia del trasplante de células madre mesenquimales de lipoaspirado en el tratamiento de lesiones crónicas del manguito rotador. Modelo experimental en ratas.

BACKGROUND AND AIM: Rotator cuff tears emerge in approximately 30% of the population over 60 years of age. Arthroscopic surgical treatment of these lesions is the treatment of choice, however, despite the improved repair techniques, the rate of re-tears ranges between 11 and 94%. Therefore, researchers seek to improve the biological healing process through the use of different alternatives such as mesenchymal stem cells (MSCs). Our objective is to evaluate the efficacy of a Cellular Therapy Drug made from allogeneic stem cells derived from adipose tissue in a rat model of chronic rotator cuff injury. MATERIAL AND METHODS: The supraspinatus lesion was created in 48 rats for subsequent suturing at 4 weeks. MSCs in suspension were added to 24 animals after suturing, and HypoThermosol-FRS® (HTS) to 24 animals as a control group. Histology (Åström and Rausing scale) and the maximum load, displacement and elastic constant of the supraspinatus tendon were analyzed in both groups 4 months after the repair. RESULTS: No statistically significant differences were found in the histological score comparing the tendons treated with MSCs with respect to the tendons treated with HTS (P=.811) nor in the results of maximum load (P=.770), displacement (P=.852) or elastic constant (P=.669) of the tendon in both groups. CONCLUSIONS: The addition of adipose-derived cells in suspension to the repair of a chronic cuff injury does not improve the histology or biomechanics of the sutured tendon.

Analysis of deep brain stimulation of the subthalamic nucleus (STN-DBS) in patients with monogenic PRKN and LRRK2 forms of Parkinson's disease.

INTRODUCTION: Deep brain stimulation of the subthalamic nucleus (STN-DBS) is the most common surgical treatment for Parkinson's disease (PD). Patient selection and genetic background can modify the response to this treatment. The objective of this study was to compare both clinical and pharmacologic response of STN-DBS between patients with monogenic forms of PD and non-mutation carriers with idiopathic PD. METHODS: A retrospective analysis among 23 carriers of genetic mutations (8 PRKN and 15 LRRK2) and 74 patients with idiopathic PD was performed. The study included comparisons of Unified Parkinson's Disease Rating Scale (UPDRS) II and III scores, Schwab and England (S&E) scale values, Hoehn & Yahr (H&Y) stage scores, and equivalent doses of levodopa before and after the surgery (at 6 and 12 months) between both groups. RESULTS: The mean age at the time in which STN-DBS was performed was 59.5 ± 8.6. Linear mixed models showed the absence of statistically significant differences between mutation and non-mutation carriers regarding levodopa doses (p = 0.576), UPDRS II (p = 0.956) and III (p = 0.512) scores, and S&E scale scores (0.758). The only difference between the two groups was observed with respect to H&Y stage in OFF medication/ON stimulation status being lower in genetic PD at 6 months after surgery (p = 0.030). CONCLUSION: Clinical and pharmacological benefit of bilateral STN-DBS is similar in PRKN and LRRK2 mutation carriers and patients with idiopathic PD.

Author Correction: Sex-biased patterns shaped the genetic history of Roma.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Sex-biased patterns shaped the genetic history of Roma.

The Roma population is a European ethnic minority characterized by recent and multiple dispersals and founder effects. After their origin in South Asia around 1,500 years ago, they migrated West. In Europe, they diverged into ethnolinguistically distinct migrant groups that spread across the continent. Previous genetic studies based on genome-wide data and uniparental markers detected Roma founder events and West-Eurasian gene flow. However, to the best of our knowledge, it has not been assessed whether these demographic processes have equally affected both sexes in the population. The present study uses the largest and most comprehensive dataset of complete mitochondrial and Y chromosome Roma sequences to unravel the sex-biased patterns that have shaped their genetic history. The results show that the Roma maternal genetic pool carries a higher lineage diversity from South Asia, as opposed to a single paternal South Asian lineage. Nonetheless, the European gene flow events mainly occurred through the maternal lineages; however, a signal of this gene flow is also traceable in the paternal lineages. We also detect a higher female migration rate among European Roma groups. Altogether, these results suggest that sociocultural factors influenced the emergence of sex-biased genetic patterns at global and local scales in the Roma population through time.

Apertura de una Unidad de Atención Farmacéutica a pacientes externos durante la pandemia COVID-19 / Setting-up of a hospital outpatient Pharmaceutical Care Unit during the COVID-19 pandemic

OBJETIVOS: Describir y analizar los cambios organizativos para la apertura de una nueva Unidad de Atención Farmacéutica a pacientes externos (UFPE) de un hospital "limpio" de SARS-COV-2 durante la pandemia y medir su impacto. MÉTODOS: Estudio llevado a cabo en un hospital de 86 camas (uso no COVID-19) dependiente de un hospital de 652 camas (con atención a pacientes COVID-19), desde el 11 de marzo al 21 de junio. Se comparó la actividad con el mismo período del año anterior y se encuestó a los pacientes. La plantilla se reforzó temporalmente con un especialista en farmacia hospitalaria. RESULTADOS: Se realizaron 886 dispensaciones a 448 pacientes, frente a 34 dispensaciones a 9 pacientes el año previo. Se encuestó a 60 pacientes, donde un 60% expresó que de haber tenido que desplazarse al hospital habitual no habrían recogido la medicación. Un 93% opinó sentirse seguro en su visita a la nueva UFPE. La evaluación de la satisfacción fue excelente. El sistema de reposición mediante método Kanban permitió reducir la solicitud de medicación al hospital principal. CONCLUSIONES: La apertura de la UFPE permitió continuar con la actividad no-COVID-19 minimizando el riesgo de contagio, mejorando así la adherencia. El método Kanban supuso un buen método de control de existencias en cantidad y tiempo. La crisis sanitaria por SARS-COV-2 ha supuesto un gran desafío y la farmacia hospitalaria ha demostrado una elevada capacidad de adaptación. El futuro inmediato en el ámbito sanitario se muestra incierto por lo que es fundamental mantenerse abierto a la incorporación de nuevas estrategias que refuercen la asistencia sanitaria

OBJECTIVE: Describe and analyze the organizational changes for the setting up of a new outpatient Pharmaceutical Care Unit (OPCU) of a "clean" SARSCOV-2 hospital during the pandemic and measure their impact. METHODS: Study carried out in an 86- bed hospital (non-COVID-19 use) dependent on a 652-bed hospital (with care for COVID-19 patients), from March 11 to June 21. Activity was compared with the same period of the previous year and patients were surveyed. The staff was temporarily reinforced with a hospital pharmacist. RESULTS: A total of 886 dispensations were made to 448 patients, compared to 34 dispensations to 9 patients the previous year. 60 patients were surveyed, where 60% expressed that if they had to go to the usual hospital they would not have collected the medication. 93% said they felt safe on their visit to the new OPCU. Satisfaction evaluation was excellent. The Kanban replenishment system reduced the request for medication to the main hospital. CONCLUSIONS: Setting-up of the OPCU allowed to continue with the non-COVID-19 activity, minimizing the risk of infection, thus improving adherence. The Kanban method was a good method of inventory control in quantity and time. Health crisis due to SARS-COV-2 has been a great challenge and the hospital pharmacy has demonstrated a high capacity for adaptation. The immediate future in the health field is uncertain, so it is essential to remain open to the incorporation of new strategies that strengthen health care

¿Es la fibromialgia causa de fracaso de una descompresión subacromial artroscópica? / Is fibromyalgia a cause of arthroscopic subacromial decompression failure?

La descompresión subacromial artroscópica aislada (DSA) es un procedimiento quirúrgico ampliamente utilizado que presenta un elevado porcentaje de éxito. Sin embargo, hasta un 25% de los pacientes puede presentar dolor residual tras la intervención. No está claro si el procesamiento aberrante del dolor, como ocurre en la fibromialgia (FM), podría ejercer un efecto deletéreo en los resultados obtenidos. Para testar esta hipótesis hemos realizado un estudio casos-controles retrospectivo de los pacientes en los que se ha realizado una descompresión subacromial artroscópica como procedimiento quirúrgico único. Material y métodos: Se seleccionaron 26 pacientes con diagnóstico preoperatorio de fibromialgia de una serie de 293 pacientes intervenidos mediante DSA entre 2008-2015. Seis pacientes se perdieron durante el seguimiento. Cada paciente con diagnóstico de fibromialgia fue emparejado con un control (n=20). Los resultados fueron evaluados mediante la escala DASH, Constant, Constant relativo a la edad y sexo (rCS) y la escala visual analógica (EVA). La satisfacción del paciente fue evaluada con una pregunta dicotómica. Se consideró fracaso del procedimiento la presencia de una puntuación superior a 3 en la EVA en el último seguimiento. Resultados: La media de edad de los grupos FM/control fue de 51/48 años, con un seguimiento medio de 36/42 meses respectivamente. Ambos grupos experimentaron una mejoría postoperatoria significativa en las escalas de EVA, DASH y rCS (p<0,001) en comparación con los valores preoperatorios. Los valores medios postoperatorios FM/control fueron Constant 63,5/74 (p=0,07), rCS 82/88 (p=0,18), DASH 38,9/20,7 (p=0,009), EVA 3,8/2,8 (p=0,2). El 85% de los pacientes del grupo control manifestaron estar satisfechos con los resultados de la cirugía frente al 55% del grupo FM (p=0,03). La tasa de fracasos en el grupo FM fue del 60% frente al 30% en el grupo control (p=0,056). Conclusiones: La fibromialgia puede ser considerada como factor pronóstico que condiciona un peor resultado postoperatorio tras DSA. Sin embargo, debido a la mejoría clínica que experimentan estos pacientes frente a su estado preoperatorio, recomendamos realizar este tratamiento quirúrgico cuando exista indicación

Isolated arthroscopic subacromial decompression (IASD) is a widely used surgical procedure with high success rates. However, up to 25% of patients experience residual pain. It is unclear whether aberrant central nervous system processing of pain as described in fibromyalgia (FM) could have a detrimental effect on outcomes. To test this hypothesis, the authors conducted a retrospective case- control study of patients undergoing IASD. Material and methods: Between 2008 and 2015, 26 patients with preoperative diagnosis of fibromyalgia and an IASD procedure were identified. Six patients were lost to follow-up. Each fibromyalgia patient was matched with one control patient (n=20) recruited from the remainder with IASD. Outcomes were assessed by DASH score (Disability Arm Shoulder and Hand), Constant (CS), relative Constant score (rCS) and Visual Analogue Scale (VAS). Patient satisfaction was determined with a single 2-level question. Failure of the IASD was defined as persistent pain (VAS>3) at last follow-up. Results: The average age of the sample was FM/Control group 51/48, with a mean follow-up of 36/42 months respectively. Both groups exhibited significant clinical improvement in the pain VAS, DASH and rCS at final follow-up (P<.001) compared with the preoperative scores. Mean postoperative scores FM/Control group were: Constant 63.5/74 (P=.07), rCS 82/88 (P=.18), DASH 38.9/20.7 (P=.009), VAS 3.8/2.8 (P=.2). Eighty-five percent of patients in the control group were satisfied with the surgery compared with 55% in the FM group (P=.03). Failure of the procedure was 60% in the FM group, and 30% in the control group (P=.056). Conclusions: Fibromyalgia can be considered a prognostic factor of a poor postoperative outcome after an IASD. However the clinical improvement experienced by these patients over their preoperative situation leads us to recommend their surgical treatment when indicated

Is fibromyalgia a cause of arthroscopic subacromial decompression failure? / ¿Es la fibromialgia causa de fracaso de una descompresión subacromial artroscópica?

Isolated arthroscopic subacromial decompression (IASD) is a widely used surgical procedure with high success rates. However, up to 25% of patients experience residual pain. It is unclear whether aberrant central nervous system processing of pain as described in fibromyalgia (FM) could have a detrimental effect on outcomes. To test this hypothesis, the authors conducted a retrospective case- control study of patients undergoing IASD. MATERIAL AND METHODS: Between 2008 and 2015, 26 patients with preoperative diagnosis of fibromyalgia and an IASD procedure were identified. Six patients were lost to follow-up. Each fibromyalgia patient was matched with one control patient (n=20) recruited from the remainder with IASD. Outcomes were assessed by DASH score (Disability Arm Shoulder and Hand), Constant (CS), relative Constant score (rCS) and Visual Analogue Scale (VAS). Patient satisfaction was determined with a single 2-level question. Failure of the IASD was defined as persistent pain (VAS>3) at last follow-up. RESULTS: The average age of the sample was FM/Control group 51/48, with a mean follow-up of 36/42 months respectively. Both groups exhibited significant clinical improvement in the pain VAS, DASH and rCS at final follow-up (P<.001) compared with the preoperative scores. Mean postoperative scores FM/Control group were: Constant 63.5/74 (P=.07), rCS 82/88 (P=.18), DASH 38.9/20.7 (P=.009), VAS 3.8/2.8 (P=.2). Eighty-five percent of patients in the control group were satisfied with the surgery compared with 55% in the FM group (P=.03). Failure of the procedure was 60% in the FM group, and 30% in the control group (P=.056). CONCLUSIONS: Fibromyalgia can be considered a prognostic factor of a poor postoperative outcome after an IASD. However the clinical improvement experienced by these patients over their preoperative situation leads us to recommend their surgical treatment when indicated.

Actividades de vida afectadas en pacientes tras artroplastia total inversa de hombro en el contexto de artropatía de manguito rotador / Patient reported activities after reverse total shoulder arthroplasty in rotator cuff arthropathy patients

Introducción y objetivos. La artroplastia total de hombro inversa en el contexto de la artropatía de manguito rotador mejora la anteversión y abducción existentes, no así las rotaciones. Nuestro objetivo es determinar la repercusión de este hecho en la realización de actividades más cotidianas. Material y métodos. Entre 2009 y 2011 se implantaron 210 artroplastias de hombro en nuestro centro. De ellas, 126 artroplastias totales de hombro inversas por artropatía de manguito rotador. El 88% eran mujeres, con una edad media en el momento de la cirugía de 81 años, encontrándose el 95% laboralmente retirados. El seguimiento medio fue de 53 meses. En cada paciente fue valorada la escala Constant, la escala visual analógica e índice de comorbilidad de Charlson, el balance articular así como la capacidad de realización de 40 actividades cotidianas, divididas según grado de demanda funcional para el hombro en un cuestionario nuevo adaptado a nuestro grupo poblacional. Resultados y discusión. El Constant medio normalizado por edad y sexo fue del 81,2%. EL valor medio de la escala visual analógica e índice de comorbilidad de Charlson medios de 3,56 y 1,69 respectivamente. Mejoría del balance articular en anteversión y abducción, no en rotaciones. Limitación para realizar actividades de baja y alta demanda funcional del 20 y 51% respectivamente, apreciándose mayor limitación en aquellas que implican rotación interna. Conclusión. La artropatía de manguito rotador en el paciente anciano tratada mediante artroplastia total de hombro inversa consigue un adecuado control analgésico y buenos resultados funcionales. Sin embargo, hay que asumir un importante riesgo de limitación en actividades cotidianas de alta demanda y que impliquen rotaciones, sobre todo interna (AU)

Introduction and objective. Reverse total shoulder arthroplasty in rotator cuff arthropathy patients, improves anteversion and abduction, but not rotational, outcomes. The main aim of this study is to determine its repercussions on daily life activities in our patients. Material and methods. Between 2009 and 2011 we implanted 210 shoulder arthroplasties, 126 of them were reverse total shoulder arthroplasty in a rotator cuff arthropathy context. About 88% were women, with a mean age at time of surgery of 81 years, 95% were retired. The mean follow up was 53 months. The Constant scale, Visual Analogue Scale, Charlson Comorbidity Index, range of motion were measured for each patient and whether they could manage 40 daily life activities by means of a new questionnaire, classifying them according toshoulder functional demand. Results and discussion. Mean normalized by sex and age Constant value was 81.2%. Mean Visual Analogue Scale and Charlson Index were 3.56 and 1.69 respectively. Improvement in anteversion and abduction, not in rotational range of motion. Limitation was found in low and high functional demand activities in 20% and 51% respectively, especially those which involved internal rotation. Conclusion. Reverse total shoulder arthroplasty treatment for RCA in the elderly, achieves adequate pain management and good functional outcomes. Nevertheless, an important risk of DLA limitation must be accepted in those which involve internal rotation or shoulder high functional demand (AU)

Patient reported activities after reverse total shoulder arthroplasty in rotator cuff arthropathy patients. / Actividades de vida afectadas en pacientes tras artroplastia total inversa de hombro en el contexto de artropatía de manguito rotador.

INTRODUCTION AND OBJECTIVE: Reverse total shoulder arthroplasty in rotator cuff arthropathy patients, improves anteversion and abduction, but not rotational, outcomes. The main aim of this study is to determine its repercussions on daily life activities in our patients. MATERIAL AND METHODS: Between 2009 and 2011 we implanted 210 shoulder arthroplasties, 126 of them were reverse total shoulder arthroplasty in a rotator cuff arthropathy context. About 88% were women, with a mean age at time of surgery of 81 years, 95% were retired. The mean follow up was 53 months. The Constant scale, Visual Analogue Scale, Charlson Comorbidity Index, range of motion were measured for each patient and whether they could manage 40 daily life activities by means of a new questionnaire, classifying them according toshoulder functional demand. RESULTS AND DISCUSSION: Mean normalized by sex and age Constant value was 81.2%. Mean Visual Analogue Scale and Charlson Index were 3.56 and 1.69 respectively. Improvement in anteversion and abduction, not in rotational range of motion. Limitation was found in low and high functional demand activities in 20% and 51% respectively, especially those which involved internal rotation. CONCLUSION: Reverse total shoulder arthroplasty treatment for RCA in the elderly, achieves adequate pain management and good functional outcomes. Nevertheless, an important risk of DLA limitation must be accepted in those which involve internal rotation or shoulder high functional demand.

Reparación de las lesiones crónicas del manguito rotador mediante diferentes compuestos / Repair of rotator cuff injuries using different composites

Objetivo. La reparación del manguito rotador se acompaña de una elevada tasa de rerrotura. Nuestro objetivo es determinar si el empleo de rhBMP-2 vehiculizada en un transportador híbrido mejora el proceso de reparación en lesiones crónicas del manguito. Material y métodos. Estudio experimental en 62 ratas. A las 4 semanas de la lesión se llevó a cabo una sutura transósea y la asignación aleatoria a uno de los 5 grupos de estudio: 1) grupo control: solo sutura; 2) grupo doble-control: se aplicó además un transportador de alginato-quitina; 3) grupo control-alginato: se añadió rhBMP-2 al alginato; 4) grupo control-quitina: se añadió rhBMP-2 a la quitina, y 5) grupo doble-muestra: se añadió rhBMP-2 a ambos componentes. A los 4 meses se evaluaron los resultados mediante estudios biomecánicos e histológicos. Resultados. En todos los casos se observó una brecha osteotendinosa macroscópicamente a las 4 semanas. La tasa de rerrotura fue del 7,5%, ocurriendo el 20% de ellas en el grupo control-alginato. En la evaluación histológica los mejores resultados se obtuvieron en el grupo doble muestra: 4,5 (3,3-5). La carga máxima soportada fue mayor en el grupo doble muestra 62,9N (59,8-69,4) presentando además una menor rigidez 12,7 (9,7-15,9). Conclusiones. El empleo de la rhBMP-2 vehiculizada en un transportador híbrido de alginato-quitina parece mejorar las características histológicas de la reparación e incrementar las propiedades biomecánicas del tendón en el contexto de una lesión crónica del manguito rotador (AU)

Aim. Rotator cuff repairs have shown a high level of re-ruptures. It is hypothesised that the use of rhBMP-2 in a carrier could improve the biomechanical and histological properties of the repair. Material and methods. Controlled experimental study conducted on 40 rats with section and repair of the supraspinatus tendon and randomisation to one of five groups: Group 1 (control) only suture; Group 2 (double control), suture and alginate-chitin carrier; Group 3 (alginate-control), the rhBMP-2 was added to the alginate; Group 4 (chitin-control) application of the rhBMP-2 to the chitin, and Group 5 (double sample): The two components of the carrier (alginate and chitin) have rhBMP-2. A biomechanical and histological analysis was performed at 4 weeks. Results. A gap was observed in all cases 4 weeks after supraspinatus detachment. The re-rupture rate was 7.5%, with 20% of them in the control-alginate Group. Histologically the best results were obtained in the double sample group: 4.5 (3.3-5.0). Double sample were also able to support higher loads to failure: 62.9N (59.8 to 69.4) with lower rigidity 12.7 (9.7 to 15.9). Conclusions. The use of alginate-chitin carrier with rhBMP-2 improves the biomechanical and histological properties of the repair site in a chronic rotator cuff tear (AU)

Repair of rotator cuff injuries using different composites. / Reparación de las lesiones crónicas del manguito rotador mediante diferentes compuestos.

AIM: Rotator cuff repairs have shown a high level of re-ruptures. It is hypothesised that the use of rhBMP-2 in a carrier could improve the biomechanical and histological properties of the repair. MATERIAL AND METHODS: Controlled experimental study conducted on 40 rats with section and repair of the supraspinatus tendon and randomisation to one of five groups: Group 1 (control) only suture; Group 2 (double control), suture and alginate-chitin carrier; Group 3 (alginate-control), the rhBMP-2 was added to the alginate; Group 4 (chitin-control) application of the rhBMP-2 to the chitin, and Group 5 (double sample): The two components of the carrier (alginate and chitin) have rhBMP-2. A biomechanical and histological analysis was performed at 4 weeks. RESULTS: A gap was observed in all cases 4 weeks after supraspinatus detachment. The re-rupture rate was 7.5%, with 20% of them in the control-alginate Group. Histologically the best results were obtained in the double sample group: 4.5 (3.3-5.0). Double sample were also able to support higher loads to failure: 62.9N (59.8 to 69.4) with lower rigidity 12.7 (9.7 to 15.9). CONCLUSIONS: The use of alginate-chitin carrier with rhBMP-2 improves the biomechanical and histological properties of the repair site in a chronic rotator cuff tear.

Early sustained unresponsiveness after short-course egg oral immunotherapy: a randomized controlled study in egg-allergic children.

BACKGROUND: No studies have evaluated the potential of egg oral immunotherapy (egg-OIT) to induce sustained unresponsiveness after discontinuing therapy following short-term treatments. OBJECTIVE: We assessed the efficacy of short-course egg-OIT to induce sustained unresponsiveness. METHODS: Sixty-one egg-allergic children, 5 to 17 years old, with positive double-blind placebo-controlled food challenge (DBPCFC) to dehydrated egg white (EW) were randomized to receive egg-OIT (OITG) for 3 months (maintenance dose one undercooked egg every 48 hours) or to continue egg avoidance diet (control group, CG) for 4 months. Children who completed egg-OIT avoided egg for 1 month. At 4 months, both groups underwent a DBPCFC. OITG participants who passed this challenge were instructed to add egg to their diet ad libitum. Immune markers were studied at different time points. RESULTS: Ninety-three percent (28/30) of OITG children were desensitized in a median of 32.5 days (IQR, 14 days). At 4 months, 1/31 (3%) in CG passed DBPCFC and 11/30 (37%) of OITG (95% CI, 14 to 51%; P = 0.003), all of them were consuming egg at 36 months. A decrease in EW, OVA and OVM skin test results and OVA-specific IgE (sIgE) levels was observed on OITG at 4 months (P = 0.001). EW-, OVA- and OVM-sIgE levels prior to the start of egg avoidance diet were lower in OITG children who passed DBPCFC at 4 months than in those who did not pass it. EW- and OVM-sIgE showed the best diagnostic performance in predicting DBPCFC result at 4 months. Levels above optimal EW-sIgE cut-off of 7.1 kU/L indicated 90% probability of failing DBPCFC. CONCLUSION: This is the first demonstration of sustained unresponsiveness with a three-month egg-OIT protocol. Almost all treated subjects were desensitized and 37% achieved sustained unresponsiveness. EW-sIgE levels at the end of treatment predicted sustained unresponsiveness. This protocol shows a new approach to OIT for egg-allergic children.

Infarto-reinfarto: estudio comparativo clínico-funcional en un programa de rehabilitación cardiaca / Infarction-reinfarction: A clinical-functional comparative study within a cardiac rehabilitation program

Introducción: Los pacientes con reinfarto de miocardio pertenecen al grupo de alto riesgo en los programas de rehabilitación cardiaca (PRC). Objetivos: Evaluar si existen diferencias basales entre pacientes infartados y reinfartados que acuden a un PRC. Analizar su respuesta tras el programa. Métodos: Estudio longitudinal retrospectivo tipo casos controles en pacientes con reinfarto de miocardio frente a pacientes con un único infarto. Muestra: 152 pacientes (76 casos y 76 controles). Periodo de estudio: del 1 de enero del 2005 al 31 de octubre del 2012. Intervención PRC en Hospital Virgen de la Victoria, Málaga. Variables: factores de riesgo cardiovascular, nivel de estrés, situación emocional, profesión, hábito de ejercicio, tipo de personalidad, percepción de salud, ergometría y ecocardiografía. Análisis estadístico: programa SPSS-15.0. Resultados: Basalmente, se observan diferencias estadísticamente significativas en casos frente a controles en: hábito de ejercicio (OR = 1,31 [1,01-1,69]), percepción de salud buena (15,2%/64%), ansiedad (66,7%/38%) depresión (46%/25%) y perímetro abdominal > 102 cm (OR = 1,8 [1,16-2,78]). Tras el programa, los pacientes re-IAM mejoran de forma significativa en el hábito de ejercicio (p = 0,00), percepción de salud buena (p = 0,00), estrés laboral (p = 0,00), ansiedad (p = 0,00), depresión (p = 0,00) y perímetro abdominal (p = 0,00). En cuanto a la cardiopatía, mejoran la función ventricular (p = 0,00) y la ergometría (0,9 METS p = 0,00; tiempo: 32,79 s, p = 0,00). Conclusiones: Los pacientes con reinfarto parten de peor hábito de ejercicio, peor percepción de salud, mayor ansiedad-depresión y obesidad central. La respuesta al programa de rehabilitación es positiva en ambos grupos, con cambios más favorables en pacientes reinfartados en cuanto a aspectos funcionales y psicológicos (AU)

Introduction: Patients with myocardial infarction recurrence belong to the group of patients at high risk in cardiac rehabilitation programs (CRP). Objectives: To assess whether there are baseline differences between single myocardial infarction patients and recurrent infarction patients. To analyze changes after a CRP. Methods: A longitudinal, retrospective, case-control study was conducted in patients with a single event of myocardial infarction compared to patients with recurrent infarction. Sample: The sample was made up of 76 cases and 76 controls. Study period: 1 January 2005 to 31 October 2012. Intervention: CRP at Virgen de la Victoria Hospital from Malaga. Study variables were cardiovascular risk factors, stress level, emotional status, profession, exercise habit, personality type, perceived health, exercise test, echocardiography. Statistical analysis was done using the SPSS-15.0. Results: At baseline statistically significant differences were observed in cases versus controls: exercise habit [OR 1.31 (1.01-1.69)], good health perception (15.2%/64%), anxiety (66,7%/38%) depression (46%/25%), abdominal circumference > 102 cm (OR: 1.8 [1.16-2.78]). After CRP, patients with infarction recurrence improved significantly in exercise habit (P=.00), health perception (P=0.00) work stress perception (P=0.00), anxiety (P=00), depression (P=00) and abdominal circumference (P=0.00), systolic function improves (P=.00) and ergometry (0.9 METS P=0.00 and 32.79 seconds P=0.00). Conclusions: Patients with recurrent myocardial infarction started the program with worse exercise habit, worse perceived health, central obesity, increased anxiety and depression. Changes after rehabilitation program were positive in both groups, with more favorable changes in recurrent infarction patients regarding functional and psychological aspects (AU)

First-principles study of the interaction between NO and large carbonaceous clusters modeling the soot surface.

First-principles calculations are performed to characterize the NO adsorption on large carbonaceous clusters modeling the surface of soot. Adsorption on the face and on the edges of perfect and defective clusters is considered in the calculations. It is shown that the first situation corresponds to physisorption and requires taking into account long-range dispersion interactions in the calculations. In contrast, interaction of NO with the unsaturated edge of a defective cluster leads preferentially to a C-N rather than to a C-O chemical binding. This indicates that soot may be an efficient sink for NO in the troposphere only if it contains a high number of unsaturated carbon atoms. From a more fundamental point of view, this study also clearly evidences that quantum calculations have to be carefully conducted when considering the interaction between radical species and carbonaceous surfaces. Problems encountered with the choice of the functional used in density functional theory approaches as well as with the size of the basis set, spin multiplicity, and spin contamination have to be systematically addressed before any relevant conclusion can be drawn.

Resultados de la reducción abierta y osteosíntesis de fracturas de húmero distal en mayores de 65 años / Results after internal fixation of humerus distal fractures in patients over than 65 years old

Introducción y objetivo. Las fracturas de húmero distal en ancianos asocian mala calidad ósea y gran conminución, lo que teóricamente dificultaría la síntesis de las mismas. Nuestro objetivo es evaluar los resultados radiológicos y funcionales del tratamiento mediante reducción abierta y fijación interna de estas fracturas. Material y métodos. Estudio retrospectivo entre los años 2005-2010 de 26 pacientes tratados mediante reducción abierta y fijación interna. Seguimiento medio de 42 meses. Al finalizar el mismo se realizó una valoración radiográfica (Knirk and Jupiter scale) y funcional mediante las escalas Mayo Elbow Performance Score y Quick-Disabilities of the Arm, Shoulder and Hand Score. La edad media fue de 76,8 años (65-89) siendo el 83% mujeres. Se encontraron 16 pacientes con fractura tipo C y 8 tipo A (según la AO). Todos fueron tratados mediante abordaje posterior. Resultados. La flexión media fue de 118,86° con un déficit de extensión medio de 25°. El 79,1% de los pacientes presentaban un grado 0-1 de artrosis. La media obtenida en las escalas funcionales fue: Quick-Disabilities of the Arm, Shoulder and Hand Score: 19,87; Mayo Elbow Performance Score: 85. Encontramos 2 casos de seudoartrosis: una de húmero distal y otra de la osteotomía del olécranon. Hallamos 2 casos de neuroapraxias cubitales y una radial que se recuperaron sin secuelas. Hubo 3 reintervenciones: 2 retiradas de material y un caso de nueva osteosíntesis. Discusión. El tratamiento con reducción abierta y osteosíntesis con placa para las fracturas tipo A y C de húmero distal en ancianos proporciona unos resultados funcionales satisfactorios para las demandas de este tipo de paciente, lo que altera escasamente la calidad de vida percibida por los mismos (AU)

Introduction and objective. Distal humerus fractures in the elderly frequently associated with poor bone quality and comminution, making it harder to achieve proper osteosynthesis. Our aim is to evaluate the radiological and functional results of open reduction and internal fixation of these fractures. Material and methods. Retrospective study of 26 patients treated by open reduction and internal fixation between the years 2005-2010. Mean follow-up was 42 months. At final follow-up, a radiography evaluation (Knirk and Jupiter score) and clinical examination using Mayo Elbow Performance Score and Quick-Disabilities of the Arm, Shoulder and Hand Score was performed. Mean age of the group was 76.8 years (65-89), with 83% of the patients being female. Sixteen patients suffered type C fractures and 8 type A by AO classification. All underwent posterior surgical approach. Results. Mean elbow flexion reached 118.86°, with a mean extension deficit of 25°. More than 3-quarters (79.1%) of the patients showed 0-1 grade degenerative changes on the X-ray films at final follow-up. Functional results reached an average 19.87 points on Quick-Disabilities of the Arm, Shoulder and Hand Score, and 85 points on Mayo Elbow Performance Score scores. Non-union occurred in 2 cases: distal humerus in one patient and olecranon osteotomy in another. Ulnar nerve neuropraxia was recorded in 2 cases, and radial nerve in one. All 3 recovered uneventfully. Revision surgery was required, with 2 patients needing hardware removal and one a new fixation. Discussion. Treatment by open reduction and internal fixation with plating in elderly people for type A and C distal humerus fractures gives good functional results regarding this population, and thus scarcely disturbs their quality of life (AU)

Assessment of an educational intervention in the management of non-critical inpatient glycemic control.

In hospitalized diabetic patients, the recommended insulin therapy is basal bolus plus correction-dose regimen instead of sliding-scale insulin. The purpose of this study was to evaluate the effect of the implementation of a new protocol based on basal bolus therapy on managing diabetes in a university hospital setting. We performed a cross-sectional study before and 12 months after a 4-month intervention period to implement a basal bolus regimen in hospitalized patients. Non-critical patients admitted into the hospital for at least 72 h were included. Changes in prescribing habits, glucose control and incidence of hypoglycemia were evaluated. An increase in the use of the new protocol and a decrease in sliding scale were observed after the intervention. In the pre-intervention group, a total of 59.2% glucose readings were between 70 and 180 mg/dL versus 57.1% after the intervention, without observing statistical differences. Significant reductions in hypoglycemia between pre- and post-intervention (13.04 vs. 4.08%, p = 0.0215) were observed. The percentage of hospitalized diabetic patients who had HbA1c was 10.43 and 4.08% in pre- and post-intervention phases, respectively. The protocol showed beneficial outcomes in terms of fewer hypoglycemia episodes and reflected a change in prescription habits, but it did not improve glycemic control. Furthermore, the percentage of patients who had an HbA1c test during their hospitalization remained very low after the intervention. This fact may seriously limit the correct management of hyperglycemia after the hospital discharge.